1. async_helpers.py (40): Old timeout_deferred, delay_cancellation, ObservableDeferred, gather_results functions — have importers and use Deferred internals (.addBoth, .callback, .errback)
2. deferred_cache.py (11): Entire DeferredCache class — used by descriptors.py
3. descriptors.py (9): @cached() decorator using DeferredCache
4. http/client.py (11): Twisted HTTP client using Producer/Consumer patterns
5. http/connectproxyclient.py (5): Twisted Protocol for HTTPS proxying
6. logging/context.py (7): Twisted fallback in run_in_background
7. Reactor entry points (~15): defer.ensureDeferred in startup/shutdown/render
These are the deep Twisted integration points — HTTP Protocol classes, the cache system, and reactor entry points. Each requires either a full class rewrite or depends on the reactor switching to asyncio.